This study wants to find out whether a combined asthma inhaler called budesonide-formoterol can help prevent asthma attacks in children aged 6 to 11. The inhaler already works well for older children and adults, but it isn't yet offered to children under 12 because there hasn't been enough research in this age group. It is a two-in-one inhaler: one medicine quickly opens up the airways to ease symptoms, and the other is a steroid that calms the swelling inside the airways that causes asthma. It can be used only when symptoms appear, or every day to keep asthma under control as well as to relieve symptoms. The study will compare this inhaler with the asthma treatments children currently use, to see how well it works, how safe it is, and whether it offers good value for money.
PROMMIS
Most women go through symptoms during and after the menopause. Hot flushes and night sweats are usually worst in the first four to seven years but can last more than ten, while vaginal and urinary symptoms often get worse over time. Other common changes include poor sleep, mood swings, problems with memory or concentration, lower sex drive, weaker bones, more fat around the tummy and changes that affect overall health.
Hormone replacement therapy (HRT) containing oestrogen is the most effective treatment for many of these symptoms, and for most women under 60 who started the menopause less than ten years ago, the benefits are thought to outweigh the risks. However, most past research has only included certain groups of women without serious health problems. Women with severe obesity, high blood pressure that isn't under control, heart disease or a recent cancer diagnosis were usually left out, and there is very little evidence on how well HRT works and how safe it is for women from ethnic minority backgrounds or those facing money or social difficulties.
This study will bring together information from large numbers of women with menopause and related conditions from centres across the country, to better understand their experiences and improve how the menopause is diagnosed and treated.
